Theoretical studies on pyridoxal 5′-phosphate-dependent transamination of α-amino acids
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Theoretical studies on pyridoxal 5'-phosphate-dependent transamination of alpha-amino acids
Density functional methods have been applied to investigate the irreversible transamination between glyoxylic acid and pyridoxamine analog and the catalytic mechanism for the critical [1,3] proton transfer step in aspartate aminotransferase (AATase). The results indicate that the catalytic effect of pyridoxal 5'-phosphate (PLP) may be attributed to its ability to stabilize related transition st...
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ژورنال
عنوان ژورنال: Journal of Computational Chemistry
سال: 2008
ISSN: 0192-8651
DOI: 10.1002/jcc.20958